The main aim is to develop a biocatalytic method for the asymmetric synthesis of alkyl fluorides.
Utilized ene reductase enzymes for the reduction process.
Targeted a diverse range of α-fluoroenones and α-fluoroenoates.
Explored biocatalytic pathways for product formation.
Successfully synthesized various alkyl fluorides through biocatalytic reduction.
Demonstrated the efficiency of ene reductase enzymes in achieving asymmetric synthesis.
Showed broad substrate compatibility with α-fluoroenones and α-fluoroenoates.
Abstract
Here we report the first biocatalytic asymmetric synthesis of alkyl fluorides via reduction of α-fluoroenones and α-fluoroenoates using ene reductase enzymes. The reduction of a wide range of (Z) or...