Asymmetric Synthesis of Alkyl Fluorides via Biocatalytic Reduction of α-Fluoroenones and α-Fluoroenoates

Helen Allan; Yu Wang; Bethan Winterson; A. S. King; Abil Aliev; Rachel Szpara; Víctor Laserna; Charlotte E. Coomber; John M. Ward; Jack Jeffries; Helen Hailes; Tom Sheppard

doi:10.1039/d6gc00545d

January 1, 2026Green ChemistryOpen Access

Asymmetric Synthesis of Alkyl Fluorides via Biocatalytic Reduction of α-Fluoroenones and α-Fluoroenoates

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Key Points

The main aim is to develop a biocatalytic method for the asymmetric synthesis of alkyl fluorides.
Utilized ene reductase enzymes for the reduction process.
Targeted a diverse range of α-fluoroenones and α-fluoroenoates.
Explored biocatalytic pathways for product formation.
Successfully synthesized various alkyl fluorides through biocatalytic reduction.
Demonstrated the efficiency of ene reductase enzymes in achieving asymmetric synthesis.
Showed broad substrate compatibility with α-fluoroenones and α-fluoroenoates.

Implication

Demonstrates effective biocatalytic reduction of α-fluoroenones in organic synthesis, implying new pathways for product formation.

Abstract

Here we report the first biocatalytic asymmetric synthesis of alkyl fluorides via reduction of α-fluoroenones and α-fluoroenoates using ene reductase enzymes. The reduction of a wide range of (Z) or...

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Cite This Study

Allan et al. (2026) studied this question.

synapsesocial.com/papers/6a06b940e7dec685947abe9c https://doi.org/10.1039/d6gc00545d

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Asymmetric Synthesis of Alkyl Fluorides via Biocatalytic Reduction of α-Fluoroenones and α-Fluoroenoates

Key Points

Implication

Abstract

Discussion

Cite This Study

Asymmetric Synthesis of Alkyl Fluorides via Biocatalytic Reduction of α-Fluoroenones and α-Fluoroenoates

Key Points

Implication

Abstract

Discussion

Cite This Study

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