Over a 38-year follow-up, intermittent claudication occurred in 381 individuals, leading to the development of a predictive risk profile based on 7 clinical factors including smoking and hypertension.
Cohort
What risk factors predict the development of intermittent claudication in a general population cohort?
A risk profile based on standard cardiovascular risk factors can identify individuals at high risk for developing intermittent claudication, allowing for targeted risk factor modification.
BACKGROUND: Intermittent claudication identifies persons at increased risk for death and disability. METHODS AND RESULTS: Using 38-year follow-up data for the original cohort in the Framingham Heart Study, we developed an intermittent claudication risk profile. Intermittent claudication occurred in a total of 381 men and women. Age, sex, serum cholesterol, hypertension, cigarette smoking, diabetes, and coronary heart disease were associated with an increased risk for claudication and were included in the profile. A pooled logistic regression model was used to compute the probability of intermittent claudication for specified levels of risk factors. CONCLUSIONS: The intermittent claudication risk profile allows physicians to identify high-risk individuals during a routine office visit and can be used to educate patients about modifiable risk factors, particularly smoking and blood pressure. Improved compliance with risk factor modification strategies may result in a beneficial impact on survival.
Murabito et al. (Tue,) conducted a cohort in Intermittent claudication. Intermittent claudication risk profile was evaluated on Intermittent claudication. Over a 38-year follow-up, intermittent claudication occurred in 381 individuals, leading to the development of a predictive risk profile based on 7 clinical factors including smoking and hypertension.
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