Key result
Over a 38-year follow-up, intermittent claudication occurred in 381 individuals, leading to the development of a predictive risk profile based on 7 clinical factors including smoking and hypertension.
Why the study?
What risk factors predict the development of intermittent claudication in a general population cohort?
Population
Original cohort in the Framingham Heart Study (381 men and women developed intermittent claudication)
Design
Cohort
Follow-up
38 years
Authors
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May aid primary prevention targeting; extends long-term observational data but leaves validation and trials open.
Cohort
What risk factors predict the development of intermittent claudication in a general population cohort?
A risk profile based on standard cardiovascular risk factors can identify individuals at high risk for developing intermittent claudication, allowing for targeted risk factor modification.
Murabito et al. (1997) conducted a cohort in Intermittent claudication. Intermittent claudication risk profile was evaluated on Intermittent claudication. Over a 38-year follow-up, intermittent claudication occurred in 381 individuals, leading to the development of a predictive risk profile based on 7 clinical factors including smoking and hypertension.
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