Standardization of Thrombotest at individual hospitals showed significant diversion due to technical errors, suggesting calibration should only occur in specialist coagulation centers.
Observational
Sí
Is the nationally adopted standardization procedure reliable for comparing the British Comparative Thromboplastin and Thrombotest at individual hospitals?
Calibration of Thrombotest against the British Comparative Thromboplastin should be restricted to specialist coagulation centres due to technical errors at individual hospitals.
A study has been made to determine whether a reliable comparison can be made between the British Comparative Thromboplastin and Thrombotest using the nationally adopted standardization procedure. The method recommended appeared sufficiently satisfactory and statistically valid for the comparison between the British Comparative Thromboplastin and Thrombotest. The degree of diversion in the location of the ;best lines', which should have been in an identical position at each centre, suggests that the standardization procedure at individual hospitals with Thrombotest is not usually a sufficiently reliable basis for clinical anticoagulant dosage. The degree of diversion almost certainly arises from technical error in the standardization procedure, and it is suggested that Thrombotest should be calibrated against the British Comparative Thromboplastin only in specialist coagulation centres thoroughly conversant with both techniques.
Poller et al. (Mon,) conducted a observational in Anticoagulant control. Thrombotest vs. British Comparative Thromboplastin was evaluated on Reliability of comparison between British Comparative Thromboplastin and Thrombotest. Standardization of Thrombotest at individual hospitals showed significant diversion due to technical errors, suggesting calibration should only occur in specialist coagulation centers.