Higher levels of IGFBP1 (HR 1.24) and NT-proBNP (HR 1.73), and lower levels of IGF1 (HR 0.84) were associated with a higher risk of incident atrial fibrillation.
Cohort (n=3,378)
Are specific protein biomarkers associated with the risk of incident atrial fibrillation in adults ≥50 years of age?
Decreased levels of IGF1 and increased levels of IGFBP1 and NT-proBNP are associated with a higher risk of incident atrial fibrillation, highlighting potential pathways for risk prediction and therapeutic development.
Estimación del efecto: HR 0.84 (95% CI 0.76-0.93)
BACKGROUND: Identification of protein biomarkers associated with incident atrial fibrillation (AF) may improve the understanding of the pathophysiology, risk prediction, and development of new therapeutics for AF. We examined the associations between 85 protein biomarkers and incident AF. METHODS: We included participants ≥50 years of age from the FHS (Framingham Heart Study) Offspring and Third Generation cohorts, who had 85 fasting plasma proteins measured using Luminex xMAP platform. Hazard ratios (per 1 SD increment of rank-normalized biomarker hazard ratio) and 95% CIs for incident AF were calculated using Cox regression models adjusted for age, sex, height, weight, current smoking, systolic blood pressure, diastolic blood pressure, hypertension treatment, diabetes mellitus, valvular heart disease, prevalent myocardial infarction, and prevalent heart failure. We used the false discovery rate to account for multiple testing. RESULTS: The study sample comprised 3378 participants (54% women) with mean (SD) age of 61.5 (8.4) years. In total, 401 developed AF over a mean follow-up of 12.3±3.8 years. We observed lower hazard of incident AF associated with higher mean levels of IGF1 (insulin-like growth factor 1; hazard ratio per 1 SD increment in protein level, 0.84 95% CI, 0.76-0.93), and higher hazard of incident AF associated with higher mean levels of both IGFBP1 (insulin-like growth factor-binding protein 1; hazard ratio, 1.24 95% CI, 1.1-1.39) and NT-proBNP (N-terminal pro-B-type natriuretic peptide; hazard ratio, 1.73 95% CI, 1.52-1.96). CONCLUSIONS: Decreased levels of IGF1 and increased levels of IGFBP1 and NT-proBNP were associated with higher risk of incident AF.
Stærk et al. (Thu,) conducted a cohort in Incident atrial fibrillation (n=3,378). Protein biomarkers (85 fasting plasma proteins) was evaluated on Incident atrial fibrillation (HR 0.84, 95% CI 0.76-0.93). Higher levels of IGFBP1 (HR 1.24) and NT-proBNP (HR 1.73), and lower levels of IGF1 (HR 0.84) were associated with a higher risk of incident atrial fibrillation.