Key result
Elevated IGFBP1 and NT-proBNP, along with reduced IGF1, are linked to greater incident atrial fibrillation risk.
Why the study?
Identifying protein biomarkers associated with incident AF may improve the understanding of pathophysiology, risk prediction, and development of new therapeutics.
Are specific protein biomarkers associated with the risk of incident atrial fibrillation in adults ≥50 years of age?
Cohort (n=3,378)
Are specific protein biomarkers associated with the risk of incident atrial fibrillation in adults ≥50 years of age?
Effect estimate: HR 0.84 (95% CI 0.76-0.93)
Decreased levels of IGF1 and increased levels of IGFBP1 and NT-proBNP are associated with a higher risk of incident atrial fibrillation, highlighting potential pathways for risk prediction and therapeutic development.
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May refine AF risk prediction in adults ≥50; leaves open causal roles for IGF-axis targeting.
Stærk et al. (2020) conducted a cohort in Incident atrial fibrillation (n=3,378). Protein biomarkers (85 fasting plasma proteins) was evaluated on Incident atrial fibrillation (HR 0.84, 95% CI 0.76-0.93). Higher levels of IGFBP1 (HR 1.24) and NT-proBNP (HR 1.73), and lower levels of IGF1 (HR 0.84) were associated with a higher risk of incident atrial fibrillation.
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