Key result
A 76-protein signature is linked to incident AF, identifying multiple causal candidates.
Why the study?
Atrial fibrillation is associated with a high risk of comorbidities and mortality, but causal and predictive relationships between circulating serum proteins and incident AF required examination.
What is the proteomic signature associated with incident atrial fibrillation, and does it improve risk prediction?
Population
4765 participants in the AGES-Reykjavik study
Comparison
Baseline serum protein levels and incident AF risk
Design
Prospective population-based cohort study and Mendelian randomization analysis
Authors
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May aid AF risk stratification; extends biomarker research but leaves clinical utility open pending trials.
Cohort (n=4,765)
What is the proteomic signature associated with incident atrial fibrillation, and does it improve risk prediction?
A large-scale proteomic analysis identified 76 proteins associated with incident AF, highlighting NT-proBNP for short-term and polygenic risk scores for long-term risk assessment.
Jónmundsson et al. (2023) conducted a cohort in Atrial fibrillation (n=4,765). Serum proteins and AF-polygenic risk score was evaluated on Incident atrial fibrillation. A proteomic signature of 76 proteins was associated with incident atrial fibrillation, identifying 9 causal candidates, while NT-proBNP and a polygenic risk score improved risk prediction.
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