Novartis (China)

Recent papers from Novartis (China)

1. Discovery of a Pyrazine-2-Carboxamide Derivative as a Potent Plasmodium falciparum Inhibitor with Potential for Single-Dose CureJournal of Medicinal Chemistry · 2026
2. The Phenotypic Hit-to-Probe ChallengeJournal of Medicinal Chemistry · 2026
3. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trialThe Lancet · 2013
4. Designing Cooperative Molecular Glues for FKBP12-MAPRE1 with Enhanced-Sampling Molecular Dynamics SimulationsJournal of the American Chemical Society · 2026
5. Stimulatrix: An open-source automated platform for high-throughput functional characterization of engineered contractile tissues2026
6. Ligand‐Promoted Cu(I)‐Catalyzed Coupling of Aryl Bromides With NH ‐Heterocycles in Aqueous Micellar ConditionsAdvanced Synthesis & Catalysis · 2026
7. Synthesis, Evaluation, and Context for Applications of SF5-Containing [1.1.1]Bicyclopentane and [ 2 ]Staffane “Hybrid Bioisosteres”Journal of the American Chemical Society · 2026
8. The Scope Concept: Defined Chemical Space for Identifying Ligand-Efficient, Tractable Hits Applied to Drug Discovery Targets Trypanosomal CLK1, 14–3–3/Estrogen Receptor-α, and SARS-CoV-2 MproJournal of Chemical Information and Modeling · 2026
9. A user-centric patient educational intervention in clinical practice: helping women to learn and share experiences about menopausePost Reproductive Health · 2026
10. IID432, a parasite-selective topoisomerase II inhibitor, achieves rapid single-dose parasite clearance in a murine chronic Chagas modelProceedings of the National Academy of Sciences · 2026
11. Effect of Sacubitril/Valsartan on Functional and Structural Cardiac Parameters in Adults With Non-Obstructive Hypertrophic CardiomyopathyJACC Heart Failure · 2025
12. Sulfoximines as Secondary Sulfonamide Isosteres: Paradoxical Impact on Solubility and Plasma Protein BindingJournal of Medicinal Chemistry · 2026
13. Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral ExposureJournal of Medicinal Chemistry · 2026
14. Textural Features from Quantitative MRI Using T2 Relaxation Times Correlate with Histological Cartilage Degeneration: An Ex-Vivo StudyCartilage · 2026
15. Covalent Stabilizers of the Interaction Between 14-3-3σand Estrogen Receptor-αACS Medicinal Chemistry Letters · 2026
16. TIM3 blockade with hypomethylating therapy restores NK-cell and cytotoxic CD4+ T-cell activity in patients with AML or MDSCancer Immunology Research · 2026
17. Neutral BackboneModifications Enhance the Pharmacokineticsand Biodistribution of Antibody–Oligonucleotide Conjugateswith High Drug-to-Antibody RatiosJournal of Medicinal Chemistry · 2026
18. Acoustic ejection native mass spectrometry for high-throughput protein-ligand screeningSLAS DISCOVERY · 2026
19. Real-world treatment pattern and clinical outcomes in Chinese NSCLC patients with KRAS G12C mutationBMC Cancer · 2026
20. Potential remote measurement of C-peptide using a minimally invasive and convenient sampling techniqueBioanalysis · 2026