What question did this study set out to answer?

This study aims to identify new prognostic biomarkers related to atrial fibrillation (AF) using a custom-made proteomics chip.

September 8, 2016Heart

Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip

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Why the study?

Are specific plasma proteins measured by a proteomics chip associated with incident atrial fibrillation in community-dwelling older adults?

Key Points

This study aims to identify new prognostic biomarkers related to atrial fibrillation (AF) using a custom-made proteomics chip.
Analyzed 92 plasma proteins in two community-based cohorts with 978 participants in PIVUS and 725 in ULSAM.
Used a proximity extension assay (PEA) for protein assessment at baseline.
Tracked incident AF over follow-up periods of 10.0 years for PIVUS and 7.9 years for ULSAM.
Identified 13 proteins related to incident AF in PIVUS (148 events) with a false discovery rate of 5%.
Replicated five proteins in ULSAM (123 events) that remained significant after adjusting for established AF risk factors.
NT-pro-BNP addition to a model of established risk factors increased the C-statistic significantly from 0.605 to 0.676 (p<0.0001).

Structured PICO

Are specific plasma proteins measured by a proteomics chip associated with incident atrial fibrillation in community-dwelling older adults?

Population

1,703 participants without atrial fibrillation from two independent community-based cohorts: PIVUS (n=978, mean age 70.1 years, 50% women) and ULSAM (n=725, mean age 77.5 years).

Intervention

Assessment of 92 plasma proteins at baseline using a custom-made proximity extension assay (PEA) proteomics chip.

Outcome

Incident atrial fibrillationhard clinical

Discussion

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Implication

May enhance AF risk stratification in older adults; hypothesis-generating and requires prospective validation before clinical use.

Cite This Study

Lind et al. (2016) studied this question.

synapsesocial.com/papers/6a25c1decd351018c0962344 https://doi.org/10.1136/heartjnl-2016-309764

Topics

Persistent AF management Atrial fibrillation

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Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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