Cardiac MR elastography demonstrated good interscan reproducibility for measuring left ventricular myocardial stiffness (rc=0.77, P<0.0001), with end-systolic stiffness increasing more with age.
Observational (n=29)
Is cardiac MR elastography reproducible for measuring left ventricular myocardial stiffness across the cardiac cycle and does it correlate with age in normal volunteers?
Cardiac MR elastography is a reproducible method for measuring left ventricular myocardial stiffness, demonstrating that end-systolic stiffness increases more than end-diastolic stiffness with advancing age.
Estimación del efecto: rc 0.77
valor p: p=< 0.0001
PURPOSE: To assess reproducibility in measuring left ventricular (LV) myocardial stiffness in volunteers throughout the cardiac cycle using MR elastography (MRE) and to determine its correlation with age. METHODS: Cardiac MRE (CMRE) was performed on 29 normal volunteers, with ages ranging from 21 to 73 years. For assessing reproducibility of CMRE-derived stiffness measurements, scans were repeated per volunteer. Wave images were acquired throughout the LV myocardium, and were analyzed to obtain mean stiffness during the cardiac cycle. CMRE-derived stiffness values were correlated to age. RESULTS: Concordance correlation coefficient revealed good interscan agreement with rc of 0.77, with P-value < 0.0001. Significantly higher myocardial stiffness was observed during end-systole (ES) compared with end-diastole (ED) across all subjects. Additionally, increased deviation between ES and ED stiffness was observed with increased age. CONCLUSION: CMRE-derived stiffness is reproducible, with myocardial stiffness changing cyclically across the cardiac cycle. Stiffness is significantly higher during ES compared with ED. With age, ES myocardial stiffness increases more than ED, giving rise to an increased deviation between the two.
Wassenaar et al. (Fri,) conducted a observational in Healthy volunteers (n=29). Cardiac MR elastography (CMRE) was evaluated on Interscan agreement of CMRE-derived stiffness measurements (rc 0.77, p=< 0.0001). Cardiac MR elastography demonstrated good interscan reproducibility for measuring left ventricular myocardial stiffness (rc=0.77, P<0.0001), with end-systolic stiffness increasing more with age.