Key result
Cardiac MR elastography shows good reproducibility for measuring LV stiffness, with end-systolic stiffness increasing with age.
Why the study?
Is cardiac MR elastography reproducible for measuring left ventricular myocardial stiffness across the cardiac cycle and does it correlate with age in normal volunteers?
Population
29 normal volunteers, ages ranging from 21 to 73 years
Design
Cross-sectional
Authors
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May enable noninvasive stiffness assessment in research; leaves open validation and clinical utility in disease.
Observational (n=29)
Is cardiac MR elastography reproducible for measuring left ventricular myocardial stiffness across the cardiac cycle and does it correlate with age in normal volunteers?
Effect estimate: rc 0.77
p-value: p=< 0.0001
Cardiac MR elastography is a reproducible method for measuring left ventricular myocardial stiffness, demonstrating that end-systolic stiffness increases more than end-diastolic stiffness with advancing age.
Wassenaar et al. (2015) conducted an observational in Healthy volunteers (n=29). Cardiac MR elastography (CMRE) was evaluated on Interscan agreement of CMRE-derived stiffness measurements (rc 0.77, p=< 0.0001). Cardiac MR elastography demonstrated good interscan reproducibility for measuring left ventricular myocardial stiffness (rc=0.77, P<0.0001), with end-systolic stiffness increasing more with age.
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