Key result
Magnetic resonance elastography and MRI-based pulse wave velocity measurements of abdominal aortic stiffness both increased with age (R2=0.81 and 0.67), but correlated poorly with each other (R2=0.43).
Why the study?
How does abdominal aortic stiffness measured by MR elastography compare to MRI-based pulse wave velocity across different ages?
Cross-Sectional (n=21)
How does abdominal aortic stiffness measured by MR elastography compare to MRI-based pulse wave velocity across different ages?
p-value: p=≤0.001
MRE and MRI-based PWV both demonstrate increased abdominal aortic stiffness with normal aging, though they correlate poorly with each other.
MRE and PWV both associate with age-related aortic stiffening; leaves open their relative value for cardiovascular risk prediction.
PURPOSE: To determine the correlation in abdominal aortic stiffness obtained using magnetic resonance elastography (MRE) (μ(MRE)) and MRI-based pulse wave velocity (PWV) shear stiffness (μ(PWV)) estimates in normal volunteers of varying age, and also to determine the correlation between μ(MRE) and μ(PWV). MATERIALS AND METHODS: In vivo aortic MRE and MRI were performed on 21 healthy volunteers with ages ranging from 18 to 65 years to obtain wave and velocity data along the long axis of the abdominal aorta. The MRE wave images were analyzed to obtain mean stiffness and the phase contrast images were analyzed to obtain PWV measurements and indirectly estimate stiffness values from the Moens-Korteweg equation. RESULTS: Both μ(MRE) and μ(PWV) measurements increased with age, demonstrating linear correlations with R(2) values of 0.81 and 0.67, respectively. Significant difference (P ≤ 0.001) in mean μ(MRE) and μ(PWV) between young and old healthy volunteers was also observed. Furthermore, a poor linear correlation of R(2) value of 0.43 was determined between μ(MRE) and μ(PWV) in the initial pool of volunteers. CONCLUSION: The results of this study indicate linear correlations between μ(MRE) and μ(PWV) with normal aging of the abdominal aorta. Significant differences in mean μ(MRE) and μ(PWV) between young and old healthy volunteers were observed.
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Damughatla et al. (2013) conducted a cross-sectional in Healthy (n=21). Magnetic resonance elastography (MRE) vs. MRI-based pulse wave velocity (PWV) was evaluated on Correlation of abdominal aortic stiffness estimates with age (p=≤0.001). Magnetic resonance elastography and MRI-based pulse wave velocity measurements of abdominal aortic stiffness both increased with age (R2=0.81 and 0.67), but correlated poorly with each other (R2=0.43).
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