Population
Open-chest dogs (n=11)
Comparison
Right ventricular outflow tract pacing and left… vs Spontaneous beating
Design
Preclinical
Key result
In open-chest dogs, the delay between basal and apical activation was consistently larger for mechanical than electrical activation during spontaneous beating (20.5 vs 8.8 ms, P<0.05).
Authors
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Should not change CRT practice; hypothesis-generating for electromechanical asynchrony mechanisms in translational models.
p-value: p=<0.05
Mechanical asynchrony in the heart exceeds electrical asynchrony because the electromechanical delay increases in later-activated regions.
Prinzen et al. (1992) studied Normal cardiac physiology (n=11). Right ventricular outflow tract pacing and left ventricular apex pacing vs. Spontaneous beating was evaluated on Delay between activation of basal and apical regions for mechanical vs electrical activation (p=<0.05). In open-chest dogs, the delay between basal and apical activation was consistently larger for mechanical than electrical activation during spontaneous beating (20.5 vs 8.8 ms, P<0.05).
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