A 1-standard deviation increase in serum albumin was associated with a reduced incidence of coronary heart disease in elderly men with elevated cholesterol (RR 0.60; 95% CI 0.38-0.96).
Cohort (n=820)
Does serum albumin level predict coronary heart disease incidence and mortality in elderly men?
Moderately low serum albumin is predictive of coronary heart disease and all-cause mortality in elderly men, independent of traditional risk factors.
Estimación del efecto: RR 0.60 (95% CI 0.38-0.96)
We investigated associations of serum albumin with the incidence and mortality of coronary heart disease among men from the Zutphen Elderly Study. In 1985, 820 men were randomly selected from a population age 64-84 years and were followed for 5 years. We adjusted relative risks for traditional risk factors (age, body mass index, diastolic blood pressure, total and high-density lipoprotein cholesterol, smoking, and alcohol consumption) and also for baseline health status indicators (white blood cell count, physician's health score, self-rated health, and history of relevant diseases). Albumin was inversely associated with the incidence of coronary heart disease only among men with elevated total cholesterol levels (> or = 6.5 mmol per liter). The relative risk for a 1-standard deviation increase (2.5 gm per liter) in albumin was 0.60 95% confidence interval (CI) = 0.38-0.96 and was not altered after additional adjustment for baseline health status. In all men, the relative risk for death due to coronary heart disease was 0.67 (95% CI = 0.49-0.92), and the relative risk was reduced to 0.84 (95% CI = 0.61-1.15) after adjustment for health status. We found comparable health status-adjusted relative risks for mortality from cardiovascular diseases (relative risk = 0.83; 95% CI = 0.67-1.02) and for mortality from all causes (relative risk = 0.86; 0.73-0.99). Independent of traditional risk factors, moderately low serum albumin is predictive of coronary heart disease and all-cause mortality in elderly men. Only part of this relation could be explained by baseline health status.
Weijenberg et al. (Wed,) conducted a cohort in Coronary heart disease (n=820). Serum albumin was evaluated on Incidence of coronary heart disease in men with total cholesterol >= 6.5 mmol/L (RR 0.60, 95% CI 0.38-0.96). A 1-standard deviation increase in serum albumin was associated with a reduced incidence of coronary heart disease in elderly men with elevated cholesterol (RR 0.60; 95% CI 0.38-0.96).