Key result
A 1-standard deviation increase in serum albumin was associated with a reduced incidence of coronary heart disease in elderly men with elevated cholesterol (RR 0.60; 95% CI 0.38-0.96).
Why the study?
Does serum albumin level predict coronary heart disease incidence and mortality in elderly men?
Population
820 men age 64-84 years from the Zutphen Elderly Study
Comparison
Serum albumin levels vs Lower vs higher serum albumin levels
Design
Cohort
Follow-up
5 years
Authors
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Hypothesis-generating for albumin as CHD predictor in elderly men; prospective studies needed before clinical adoption.
Cohort (n=820)
Does serum albumin level predict coronary heart disease incidence and mortality in elderly men?
Effect estimate: RR 0.60 (95% CI 0.38-0.96)
Moderately low serum albumin is predictive of coronary heart disease and all-cause mortality in elderly men, independent of traditional risk factors.
Weijenberg et al. (1997) conducted a cohort in Coronary heart disease (n=820). Serum albumin was evaluated on Incidence of coronary heart disease in men with total cholesterol >= 6.5 mmol/L (RR 0.60, 95% CI 0.38-0.96). A 1-standard deviation increase in serum albumin was associated with a reduced incidence of coronary heart disease in elderly men with elevated cholesterol (RR 0.60; 95% CI 0.38-0.96).
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