Accurate definition of heart failure with preserved ejection fraction epidemiological boundaries and phenotypes is mandatory to develop novel effective and rational therapeutic approaches.
Highlights the need for accurate definitions of HFpEF epidemiological boundaries and phenotypes to develop effective therapies.
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and is associated with relevant morbidity and mortality. However, an evidence-based treatment is still absent. The heterogeneous definitions, differences in aetiology/pathophysiology, and diagnostic challenges of HFpEF made it difficult to define its epidemiological landmarks so far. Several large registries and observational studies have recently disclosed an increasing incidence/prevalence, as well as its prognostic significance. An accurate definition of HFpEF epidemiological boundaries and phenotypes is mandatory to develop novel effective and rational therapeutic approaches.
Gentile et al. (Thu,) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Accurate definition of heart failure with preserved ejection fraction epidemiological boundaries and phenotypes is mandatory to develop novel effective and rational therapeutic approaches.