Key result
Accurate definition of HFpEF boundaries and phenotypes is mandatory to develop effective novel therapies.
Why the study?
Heterogeneous definitions, pathophysiological differences, and diagnostic challenges have made it difficult to define HFpEF epidemiological landmarks, limiting the development of evidence-based treatments.
Design
Review
Authors
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HFpEF therapy development awaits accurate phenotyping; leaves open novel approaches until epidemiological boundaries are clarified.
Highlights the need for accurate definitions of HFpEF epidemiological boundaries and phenotypes to develop effective therapies.
Gentile et al. (2021) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Accurate definition of heart failure with preserved ejection fraction epidemiological boundaries and phenotypes is mandatory to develop novel effective and rational therapeutic approaches.
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