October 5, 2019Journal of the American Heart AssociationOpen Access

Noncardiac Versus Cardiac Mortality in Heart Failure With Preserved, Midrange, and Reduced Ejection Fraction

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Why the study?

A thorough analysis of noncardiac determinants of mortality in HF is missing, and evidence conflicts regarding outcomes in patients with HF and no or mild systolic dysfunction.

Population

2791 stable HF patients across HFrEF, HFmrEF, and HFpEF

Comparison

HFpEF vs HFmrEF vs HFrEF

Design

Cohort study

Follow-up

39 months

Authors

GVGiuseppe VergaroHeart Failure & Transplant NGNicolò GhionzoliUniversity of Siena LILisa InnocentiUniversity of Siena

Discussion

Member takes

Implication

Noncardiac mortality predominates in HFpEF/HFmrEF; leaves open whether competing-risk interventions improve outcomes.

Structured PICO

Population

2791 stable heart failure (HF) patients, classified into HF with reduced ejection fraction (HFrEF; LVEF <40%), HF with midrange EF (HFmrEF; LVEF 41-49%), or HF with preserved EF (HFpEF; LVEF ≥50%)

Outcome

All-cause, cardiac, and noncardiac mortality (adjudicated as due to cancer, sepsis, respiratory disease, renal disease, or other causes) over 39 months follow-uphard clinical

Noncardiac death is a major determinant of outcome in stable heart failure, exceeding cardiac-related mortality in patients with preserved and midrange ejection fraction.

Cite This Study

Vergaro et al. (2019) studied this question.

synapsesocial.com/papers/6a70d0973ce530166bc2ee43 https://doi.org/10.1161/jaha.119.013441

Topics

HFrEF treatment Heart failure Echocardiography HFpEF management

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Noncardiac Versus Cardiac Mortality in Heart Failure With Preserved, Midrange, and Reduced Ejection Fraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Noncardiac Versus Cardiac Mortality in Heart Failure With Preserved, Midrange, and Reduced Ejection Fraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider