Mechanism of Rhizoma Phragmitis-Semen Coicis Couplet Medicines in the Treatment of Postoperative Pneumonia in Thoracic Surgery Based on Network Pharmacology

Puntos clave

• This study aims to elucidate the mechanisms through which Rhizoma Phragmitis and Semen Coicis treat postoperative pneumonia using network pharmacology.
• Utilized multiple databases, including TCMSP and PubChem, to identify target genes.
• Constructed herbal-component-target networks and performed GO and KEGG enrichment analyses.
• Conducted molecular docking to verify the interactions of active components with disease targets.
• Identified 10 active components and predicted 252 targets; gathered 2,627 disease targets to yield 127 key 'drug-disease' targets.
• Mapped protein-protein interaction networks with core targets including MAPK3, JAK1, and PRKCD.
• Enrichment analyses revealed involvement in signal pathways like G protein-coupled receptor signaling and calcium ion regulation.