Mechanism of Rhizoma Phragmitis-Semen Coicis Couplet Medicines in the Treatment of Postoperative Pneumonia in Thoracic Surgery Based on Network Pharmacology

March 1, 2026Guangming Journal of Chinese Medicine

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Key Points

This study aims to elucidate the mechanisms through which Rhizoma Phragmitis and Semen Coicis treat postoperative pneumonia using network pharmacology.
Utilized multiple databases, including TCMSP and PubChem, to identify target genes.
Constructed herbal-component-target networks and performed GO and KEGG enrichment analyses.
Conducted molecular docking to verify the interactions of active components with disease targets.
Identified 10 active components and predicted 252 targets; gathered 2,627 disease targets to yield 127 key 'drug-disease' targets.
Mapped protein-protein interaction networks with core targets including MAPK3, JAK1, and PRKCD.
Enrichment analyses revealed involvement in signal pathways like G protein-coupled receptor signaling and calcium ion regulation.

Shows the mechanism of herbal medicines against pneumonia in thoracic surgery, suggesting new treatment possibilities.

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BU et al. (2026) studied this question.

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