In healthy men, SI(DVP) was strongly associated with age (R=0.63, P<0.001) and may be a better index of vascular aging than d/a, while RI(DVP) reliably reflects the effects of vasoactive drugs.
Observational (n=124)
Are RI(DVP) and SI(DVP) more reliable indices of vascular aging and vasoactive drug effects compared to second derivative indices of the digital volume pulse in healthy men?
SI(DVP) is a reliable index of vascular aging, while RI(DVP) is a reliable index for assessing the effects of vasoactive drugs, outperforming second derivative indices.
Estimación del efecto: R = 0.63 for SI(DVP), R = -0.66 for d/a
valor p: p=<.001
BACKGROUND: Indices of pressure wave reflection (RI(DVP)) and large artery stiffness (SI(DVP)) can be derived from the digital volume pulse (DVP). Indices obtained from the second derivative of the DVP have also been proposed to characterize vascular aging and effects of vasoactive drugs. METHODS: We compared RI(DVP) and SI(DVP) with the indices a/b, a/c, a/d, and a/e calculated from sequential peaks of the second derivative of the DVP in 124 healthy men. The DVP was obtained by measuring infrared light transmission through the finger. In 10 men measurements were obtained at baseline and during intravenous infusion of glyceryl trinitrate (GTN, 3 to 300 microg/min) and, on separate occasions, angiotensin II (AII, 75 to 300 microg/min) and saline vehicle. RESULTS: SI(DVP) was strongly associated with age (R = 0.63, P <.001) but little influenced by AII or GTN. RI(DVP) was weakly associated with age but showed a consistent dose-dependent increase during AII and a decrease during GTN. d/a was strongly associated with age (R = -0.66, P <.001), influenced by vasoactive drugs but did not change in a dose-dependent manner during GTN. Other second derivative indices were less strongly correlated with age and showed an inconsistent response to vasoactive drugs. Within subject standard deviations of SI(DVP) and d/a for measurements on different occasions were 2.1 and 5.4 "years of vascular aging" respectively. CONCLUSIONS: In healthy men, RI(DVP) may be a more reliable index of the effects of vasoactive drugs than d/a. SI(DVP) is similarly associated with age as is d/a, but less variable and may thus be a better index of vascular aging.
Sandrine Millasseau (Sun,) conducted a observational in Healthy (n=124). Glyceryl trinitrate (GTN) and Angiotensin II (AII) vs. Saline vehicle was evaluated on Association of SI(DVP) and d/a with age (R = 0.63 for SI(DVP), R = -0.66 for d/a, p=<.001). In healthy men, SI(DVP) was strongly associated with age (R=0.63, P<0.001) and may be a better index of vascular aging than d/a, while RI(DVP) reliably reflects the effects of vasoactive drugs.
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