Key result
In healthy men, SI(DVP) was strongly associated with age (R=0.63, P<0.001) and may be a better index of vascular aging than d/a, while RI(DVP) reliably reflects the effects of vasoactive drugs.
Why the study?
Are RI(DVP) and SI(DVP) more reliable indices of vascular aging and vasoactive drug effects compared to second derivative indices of the digital volume pulse in healthy men?
Population
124 healthy men
Comparison
Intravenous infusion of glyceryl trinitrate and… vs Saline vehicle
Design
Cross-sectional
Authors
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SI(DVP) may index vascular aging and RI(DVP) drug effects in healthy men; extends DVP research but hypothesis-generating.
Observational (n=124)
Are RI(DVP) and SI(DVP) more reliable indices of vascular aging and vasoactive drug effects compared to second derivative indices of the digital volume pulse in healthy men?
Effect estimate: R = 0.63 for SI(DVP), R = -0.66 for d/a
p-value: p=<.001
SI(DVP) is a reliable index of vascular aging, while RI(DVP) is a reliable index for assessing the effects of vasoactive drugs, outperforming second derivative indices.
Sandrine Millasseau (2003) conducted an observational in Healthy (n=124). Glyceryl trinitrate (GTN) and Angiotensin II (AII) vs. Saline vehicle was evaluated on Association of SI(DVP) and d/a with age (R = 0.63 for SI(DVP), R = -0.66 for d/a, p=<.001). In healthy men, SI(DVP) was strongly associated with age (R=0.63, P<0.001) and may be a better index of vascular aging than d/a, while RI(DVP) reliably reflects the effects of vasoactive drugs.
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