What question did this study set out to answer?

Characterize dynamic vascular changes and evaluate an index of aortic stiffness (delta P/delta V) across age groups and in isolated systolic hypertension.

December 1, 1995Clinical CardiologyOpen Access

Vascular dynamics in isolated systolic arterial hypertension

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Why the study?

How does aortic stiffness change with advanced age and isolated systolic hypertension?

Population

62 individuals, distributed in seven age groups from the second to the seventh decade.

Comparison

Measurement of aortic stiffness index using a… vs Comparison across age groups and between…

Design

Cross-sectional

Authors

EMEduardo MeaneyMinisterio de la Presidencia, Relaciones con las Cortes y Memoria Democrática ESEnrique SolteroGeisinger Medical Center VSVirginia Corina SamaniegoPontificia Universidad Católica Argentina

Discussion

Member takes

Implication

Aortic stiffness increases markedly with age and ISH; hypothesis-generating for targeted therapies but should not yet change practice.

Key Points

Characterize dynamic vascular changes and evaluate an index of aortic stiffness (delta P/delta V) across age groups and in isolated systolic hypertension.
Assessed 55 healthy individuals and 7 patients with isolated systolic hypertension stratified across seven age groups from the second to seventh decades.
Calculated an aortic stiffness index (delta P/delta V) using pulse pressure obtained by mercury sphygmomanometry and aortic volumes derived via ultrasonographic measurements.
Normotensive subjects aged 65 ± 2 years showed a 2.6-fold increase in aortic stiffness compared to young subjects, whereas elderly patients with ISH showed a 7-fold increase compared to subjects aged 15 ± 2 years (p < 0.001).
Elderly patients with ISH demonstrated a 2.7-fold increase in aortic stiffness relative to age-matched normotensive controls aged 65 ± 2 years.
Arterial stiffness strongly correlated with systolic pressure (r = 0.953, p < 0.001), Hirai's index (r = 0.989, p < 0.001), and Stefanadis' distensibility index (r = 0.932, p < 0.003).

Structured PICO

How does aortic stiffness change with advanced age and isolated systolic hypertension?

Population

62 individuals (55 healthy normotensive subjects and 7 patients with isolated systolic hypertension), distributed in seven age groups from the second to the seventh decade.

Intervention

Measurement of aortic stiffness index (delta P/delta V) using a mercury sphygmomanometer and ultrasonographic measurements.

Comparator

Comparison across age groups and between normotensive subjects and those with isolated systolic hypertension.

Outcome

Aortic stiffness index (delta P/delta V).surrogate

The delta P/delta V index is a sensitive method to estimate dynamic changes in aortic stiffness, which increases significantly with age and isolated systolic hypertension.

Cite This Study

Meaney et al. (1995) studied this question.

synapsesocial.com/papers/6a79fe24bdf697b3de0275db https://doi.org/10.1002/clc.4960181207

Topics

Hypertension management

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Vascular dynamics in isolated systolic arterial hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Vascular dynamics in isolated systolic arterial hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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