Key result
Arterial stiffness increases with age and cardiovascular risk factors, and is independently associated with target organ damage and increased risk for cardiovascular morbidity and mortality.
Design
Review
Authors
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May inform risk stratification in older hypertensive patients; leaves open whether targeting stiffness improves outcomes in trials.
Arterial stiffness is a key mechanism underlying isolated systolic hypertension in older adults and represents a potential therapeutic target to reduce cardiovascular morbidity.
Ernesto L. Schiffrin (2004) conducted a review in Isolated systolic hypertension. Arterial stiffness was evaluated. Arterial stiffness increases with age and cardiovascular risk factors, and is independently associated with target organ damage and increased risk for cardiovascular morbidity and mortality.
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