Key result
Antihypertensive drugs decrease central aortic systolic pressure by reducing wave reflection, a beneficial effect that is not detected by standard peripheral blood pressure measurements.
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Central pressure reduction may inform therapy beyond brachial readings; leaves open whether targeting it improves outcomes.
Michael R. OʼRourke (1990) studied this question. Antihypertensive drugs decrease central aortic systolic pressure by reducing wave reflection, a beneficial effect that is not detected by standard peripheral blood pressure measurements.
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