Serum uric acid is associated with carotid intima-media thickness in asymptomatic prepubertal children, with stronger relationships in heavier children (β=0.247, P<0.001).
Cross-Sectional (n=359)
Is serum uric acid associated with carotid intima-media thickness in asymptomatic prepubertal children, and is this modulated by BMI and preperitoneal fat?
Higher serum uric acid is associated with increased carotid intima-media thickness in prepubertal children, an effect aggravated by higher BMI and preperitoneal fat.
valor p: p=<0.001
BACKGROUND: Increased uric acid is an independent biomarker for cardiovascular disease in obese adolescents and adults. OBJECTIVE: We investigated whether uric acid relates to carotid intima-media thickness (cIMT) in prepubertal children, and whether body mass index (BMI) and preperitoneal fat modulate this association. METHODS: 359 asymptomatic prepubertal Caucasian children were stratified according to BMI categories (171 with BMI-SDS 50th centile). Uric acid levels, insulin resistance (homeostasis model assessment insulin resistance; HOMA-IR), C-reactive protein (CRP), triacylglycerol (TG), systolic blood pressure (SBP), abdominal fat and cIMT (both by ultrasound) were assessed. RESULTS: Uric acid was associated with several cardiovascular risk factors, namely higher HOMA-IR, CRP, TG, BMI, waist, SBP, preperitoneal fat and cIMT (all P < 0.001 to P < 0.0001). Significant BMI and preperitoneal fat interactions were documented in the relationship between uric acid and cIMT (both P < 0.05), as uric acid was preferentially related to cIMT in heavier children (β = 0.247, P < 0.001, r(2) = 9.1%) and in children with more preperitoneal fat (β = 0.263, P < 0.0001, r(2) = 11.9%). CONCLUSIONS: Serum uric acid is associated with cIMT in asymptomatic prepubertal children. Both higher BMI and preperitoneal fat aggravate the potential risk of atherosclerotic disease imposed by higher concentrations of uric acid.
Bassols et al. (Fri,) conducted a cross-sectional in Asymptomatic prepubertal children (n=359). Uric acid was evaluated on Association between uric acid and carotid intima-media thickness (p=<0.001). Serum uric acid is associated with carotid intima-media thickness in asymptomatic prepubertal children, with stronger relationships in heavier children (β=0.247, P<0.001).
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