Pulmonary vein isolation significantly improved left ventricular ejection fraction from 41% to 51% (P=0.004) at 6 months in patients with paroxysmal atrial fibrillation and baseline LVEF <50%.
Cohort (n=70)
Does pulmonary vein isolation improve cardiac function in patients with paroxysmal atrial fibrillation and impaired LVEF?
Pulmonary vein isolation significantly improves left ventricular ejection fraction in patients with paroxysmal atrial fibrillation and impaired baseline cardiac function.
Tasa de eventos absoluta: 51% vs 41%
valor p: p=0.004
AIMS: Beneficial effects of atrial fibrillation (AF) ablation have been demonstrated in patients with congestive heart failure (CHF) and significantly impaired left ventricular ejection fraction (LVEF). However, the impact of pulmonary vein isolation (PVI) on cardiac function in patients with paroxysmal AF and impaired LVEF remains under discussion. This study aimed to evaluate the impact of PVI for paroxysmal AF on cardiac function in patients with impaired LVEF using cardiac magnetic resonance imaging (CMRI). METHODS AND RESULTS: A total number of 70 patients with paroxysmal AF and episodes 50% (group 2, n = 52). Group 1 patients demonstrated a significant lower success rate than patients of group 2 after a follow-up of 152 +/- 40 days (50 vs. 73%, P < 0.05). Cardiac magnetic resonance imaging in group 1 patients demonstrated a significant improvement in cardiac function after AF ablation (41 +/- 6 vs. 51 +/- 12%, P = 0.004), whereas group 2 patients did not show significant differences (60 +/- 6 vs. 59 +/- 9%, P = 0.22) after a 6 months follow-up. CONCLUSION: Pulmonary vein isolation improves cardiac function in patients with paroxysmal AF and impaired LVEF. These data suggest that an impaired LV function can be partially attributed to AF with short-lasting paroxysms.
Lutomsky et al. (Thu,) conducted a cohort in Paroxysmal atrial fibrillation (n=70). Pulmonary vein isolation (PVI) vs. Baseline (pre-ablation) was evaluated on Left ventricular ejection fraction (LVEF) (p=0.004). Pulmonary vein isolation significantly improved left ventricular ejection fraction from 41% to 51% (P=0.004) at 6 months in patients with paroxysmal atrial fibrillation and baseline LVEF <50%.