An 8-week exercise training regimen improved insulin-stimulated glucose disposal and increased the vasodilatory response to acetylcholine in overweight and type 2 diabetic subjects (P<0.05).
Observational
Does an 8-week exercise training regimen improve vasodilatory function and insulin sensitivity in overweight, insulin-resistant subjects and type 2 diabetic patients?
An 8-week aerobic exercise training regimen improves both endothelium-dependent vasodilation and insulin sensitivity in overweight and type 2 diabetic patients.
valor p: p=<0.05
OBJECTIVE: The present study was undertaken to determine whether improved vasodilatory function accompanies increased insulin sensitivity in overweight, insulin-resistant subjects (OW) and type 2 diabetic patients (T2DM) who participated in an 8-wk exercise training regimen. DESIGN: Before and after training, subjects had euglycemic clamps to determine insulin sensitivity. Brachial artery catheterization was done on another occasion for measurement of vasodilatory function. A lean, healthy, untrained group was studied as nonexercised controls. RESULTS: Training increased oxygen consumption (VO2) peak OW, 29 +/- 1 to 37 +/- 4 ml/kg fat-free mass (FFM).min; T2DM, 33 +/- 2 to 43 +/- 3 ml/kg FFM.min; P < 0.05 and improved insulin-stimulated glucose disposal (OW, 6.5 +/- 0.5 to 7.2 +/- 0.4 mg/kg FFM.min; T2DM, 3.8 +/- 0.3 to 4.2 +/- 0.3 mg/kg FFM.min; P < 0.05) in insulin resistance. OW and T2DM, before training, had decreased acetylcholine chloride (ACh)- and sodium nitroprusside-mediated vasodilation and decreased reactive hyperemia compared with lean controls. Training increased the vasodilatory response to ACh OW (30 microg ACh/min), 12.2 +/- 3.4 to 19 +/- 4.2 ml/100 g.min; T2DM (30 microg ACh/min), 10.1 +/- 1.5 to 14.2 +/- 2.1 ml/100 g.min; P < 0.05 in both groups without affecting nitroprusside response. CONCLUSION: Because vasodilatory dysfunction has been postulated to contribute to insulin resistance, the exercise-induced improvement in vasodilatory function may signify changes in the endothelium that could contribute to the improvement in insulin sensitivity observed after aerobic exercise training.
Filippis et al. (Mié,) realizaron una observación en individuos con sobrepeso, resistencia a la insulina y diabetes mellitus tipo 2. Se evaluó el régimen de entrenamiento físico versus controles no ejercitados, sanos y delgados en sensibilidad a la insulina y función vasodilatadora (p=<0.05). Un régimen de entrenamiento físico de 8 semanas mejoró la disposición de glucosa estimulada por insulina y aumentó la respuesta vasodilatadora a la acetilcolina en sujetos con sobrepeso y diabéticos tipo 2 (P<0.05).
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