Each 1-standard deviation increase in leg fat index was associated with a lower risk of incident heart failure (HR 0.79; 95% CI 0.73-0.85), whereas arm and trunk fat showed no association.
Cohort
Does regional fat distribution predict incident heart failure in the general population without cardiovascular disease?
Higher leg fat index, but not arm or trunk fat, is associated with a lower risk of incident heart failure in individuals without baseline cardiovascular disease.
Estimación del efecto: HR 0.79 (95% CI 0.73-0.85)
BACKGROUND: Obesity is associated with a high risk of heart failure. However, the contribution of regional fat distribution evaluated using bioimpedance analysis toward heart failure risk in the general population without cardiovascular disease has rarely been studied. METHODS: ). This study evaluated the association of regional fat mass (arm fat index AFI, trunk fat index TFI, and leg fat index LFI) with the risk of incident heart failure and whether regional fat mass adds a further prognostic value for heart failure besides body mass index (BMI) in a large prospective cohort study. RESULTS: During the median 12.1 years, 3134 incident heart failure cases occurred. After adjustment for BMI and other confounding factors, each 1-standard deviation increase in LFI was associated with a 21% lower heart failure risk even after adjusting for BMI and other confounding factors (hazard ratio HR 0.79; 95% confidence interval CI, 0.73-0.85). However, we did not observe heart failure-associated risks with AFI and TFI (HR 1.04; 95% CI, 0.99-1.09; HR 0.97, 95% CI, 0.91-1.04, respectively). Subgroup analysis demonstrated that the protective role of LFI was more prominent in the elderly and female participants (P < .01). CONCLUSION: Regional fat measurement other than BMI can improve heart failure risk stratification; leg fat plays a protective role, yet arm and trunk fat do not, in the general population without cardiovascular disease.
Xing et al. (Thu,) conducted a cohort in General populations without cardiovascular disease. Regional fat mass (leg, arm, and trunk fat indices) vs. Body mass index (BMI) was evaluated on Incident heart failure (HR 0.79, 95% CI 0.73-0.85). Each 1-standard deviation increase in leg fat index was associated with a lower risk of incident heart failure (HR 0.79; 95% CI 0.73-0.85), whereas arm and trunk fat showed no association.