Myocardial stiffness was significantly correlated with plasma BNP levels in patients with both diastolic (P=0.004) and systolic (P=0.003) heart failure.
Observational (n=49)
Does myocardial stiffness correlate with plasma BNP levels in patients with diastolic and systolic heart failure?
Myocardial stiffness is a major determinant of steady-state plasma BNP production in both diastolic and systolic heart failure.
valor p: p=0.004 (DHF), 0.003 (SHF)
AIMS: Plasma brain natriuretic peptide (BNP) concentration increases in proportion to heart failure (HF) severity. Although plasma BNP decreases to a certain level by optimal treatment, there is significant heterogeneity in the baseline value among individuals. The underlying mechanism of the steady-state plasma BNP levels remains still controversial. We investigated the hypothesis that myocardial stiffness (K(m)) is a major determinant of the plasma BNP level. METHODS AND RESULTS: In 19 patients with diastolic HF DHF; left ventricular ejection fraction (LVEF) > or =4 5%, 18 with systolic HF (SHF; LVEF < 45%), and 12 controls, left ventricular (LV) performance variables and the results of the stress-strain analyses were obtained by the combined simultaneous measurement of echocardiographic and haemodynamic data, and compared with the plasma BNP level. In DHF, a significant correlation was observed between plasma BNP and fractional shortening (P = 0.010), pulmonary capillary wedge pressure (P = 0.030), end-diastolic pressure (P = 0.006), time constant of the LV isovolumic-pressure decline (P = 0.049), end-diastolic stress (P = 0.012), and K(m) (P = 0.004), respectively. In SHF, a significant correlation was observed between plasma BNP and end-diastolic stress (P = 0.036), chamber stiffness (P = 0.048), and K(m) (P = 0.003), respectively. CONCLUSION: In stable conditions, K(m) may be the most important determinant of the plasma BNP production in patients with both DHF and SHF.
Watanabe et al. (Tue,) conducted a observational in Diastolic and systolic heart failure (n=49). Myocardial stiffness (Km) assessment vs. Controls was evaluated on Correlation between plasma BNP level and myocardial stiffness (Km) (p=0.004 (DHF), 0.003 (SHF)). Myocardial stiffness was significantly correlated with plasma BNP levels in patients with both diastolic (P=0.004) and systolic (P=0.003) heart failure.