Intracoronary application of bFGF to infarcted swine myocardium significantly increased microvessel counts in viable (141 vs 39 per field, p=0.01) and nonviable tissue (329 vs 95, p<0.001).
Does intracoronary injection of basic fibroblast growth factor enhance angiogenesis in infarcted swine myocardium?
Intracoronary application of bFGF enhances myocardial neovascularization in a swine model of myocardial infarction within 2 weeks, though without significant differences in regional wall motion.
Tasa de eventos absoluta: 141% vs 39%
valor p: p=0.01
OBJECTIVES: This study was performed to examine the effect of intracoronary exogenous basic fibroblast growth factor (bFGF) on angiogenesis in infarcted myocardial regions. BACKGROUND: Exogenous bFGF is a potent promoter of angiogenesis. Little information is available on its effect on myocardial angiogenesis. METHODS: Myocardial infarction was induced in 10 pigs by intracoronary injection of microscopic beads. Four pigs served as a control group; in six pigs slow-release bFGF was delivered by the beads. Cardiac performance was evaluated by repeated echocardiographic measurement and angiogenesis was evaluated by immunohistochemical studies 14 days later. RESULTS: As compared with control pigs, pigs treated with bFGF had higher microvessel counts (mean +/- SEM) in both viable tissue (141 +/- 27 per field vs. 39 +/- 4, p = 0.01) and nonviable tissue (329 +/- 26 per field vs. 95 +/- 7, p < 0.001) within the infarct area. No significant differences in total regional left ventricular wall motion were noted between the two groups throughout the 14-day study period. CONCLUSIONS: In the swine, direct intracoronary application of bFGF to infarcted myocardium enhances myocardial neovascularization within 2 weeks.
Battler et al. (Wed,) conducted a other in Myocardial infarction (n=10). Intracoronary slow-release basic fibroblast growth factor (bFGF) vs. Control group was evaluated on Microvessel counts in viable tissue within the infarct area (p=0.01). Intracoronary application of bFGF to infarcted swine myocardium significantly increased microvessel counts in viable (141 vs 39 per field, p=0.01) and nonviable tissue (329 vs 95, p<0.001).