Key result
Intracoronary bFGF increases microvessel counts ~260% in viable infarcted swine myocardium.
Why the study?
Exogenous bFGF promotes angiogenesis, but little information was available on its effect on myocardial angiogenesis in infarcted regions.
Does intracoronary injection of basic fibroblast growth factor enhance angiogenesis in infarcted swine myocardium?
Does intracoronary injection of basic fibroblast growth factor enhance angiogenesis in infarcted swine myocardium?
Absolute Event Rate: 141% vs 39%
p-value: p=0.01
Intracoronary application of bFGF enhances myocardial neovascularization in a swine model of myocardial infarction within 2 weeks, though without significant differences in regional wall motion.
Caution against clinical use of bFGF post-MI; hypothesis-generating for angiogenesis in large-animal models.
OBJECTIVES: This study was performed to examine the effect of intracoronary exogenous basic fibroblast growth factor (bFGF) on angiogenesis in infarcted myocardial regions. BACKGROUND: Exogenous bFGF is a potent promoter of angiogenesis. Little information is available on its effect on myocardial angiogenesis. METHODS: Myocardial infarction was induced in 10 pigs by intracoronary injection of microscopic beads. Four pigs served as a control group; in six pigs slow-release bFGF was delivered by the beads. Cardiac performance was evaluated by repeated echocardiographic measurement and angiogenesis was evaluated by immunohistochemical studies 14 days later. RESULTS: As compared with control pigs, pigs treated with bFGF had higher microvessel counts (mean +/- SEM) in both viable tissue (141 +/- 27 per field vs. 39 +/- 4, p = 0.01) and nonviable tissue (329 +/- 26 per field vs. 95 +/- 7, p < 0.001) within the infarct area. No significant differences in total regional left ventricular wall motion were noted between the two groups throughout the 14-day study period. CONCLUSIONS: In the swine, direct intracoronary application of bFGF to infarcted myocardium enhances myocardial neovascularization within 2 weeks.
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Battler et al. (1993) studied Myocardial infarction (n=10). Intracoronary slow-release basic fibroblast growth factor (bFGF) vs. Control group was evaluated on Microvessel counts in viable tissue within the infarct area (p=0.01). Intracoronary application of bFGF to infarcted swine myocardium significantly increased microvessel counts in viable (141 vs 39 per field, p=0.01) and nonviable tissue (329 vs 95, p<0.001).
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