What question did this study set out to answer?

Summarize the physiological functions, receptor interactions, and developmental roles of basic and acidic fibroblast growth factors and their relationship to oncogenes.

August 1, 1990Clinical Orthopaedics and Related Research

Fibroblast Growth Factor

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Authors

DGDenis GospodarowiczÉcole Normale Supérieure de Lyon

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Implication

Review reveals essential morphogenic and mitogenic roles of fibroblast growth factors in early embryonic development, highlighting mechanisms underlying tissue formation and oncogenesis.

Key Points

Summarize the physiological functions, receptor interactions, and developmental roles of basic and acidic fibroblast growth factors and their relationship to oncogenes.
Synthesized molecular and biological data regarding receptor binding and activities of basic and acidic fibroblast growth factors.
Assessed functional outcomes during early blastula stages and cellular differentiation across mesodermal and neuroectodermal tissues.
Basic and acidic FGF bind the same receptor and exert dual mitogenic and morphogenic effects across mesoderm- and neuroectoderm-derived lineages.
Basic FGF functions as a ventrovegetalizing factor at the midblastulae stage, directly inducing ectodermally destined animal pole cells to adopt mesodermal fates.
Structural homology links FGF to five distinct oncogenes implicated in bladder, stomach, and mammary tumorigenesis.

Cite This Study

Denis Gospodarowicz (1990) studied this question.

synapsesocial.com/papers/6a18e1dfa09e0bfd307c1235 https://doi.org/10.1097/00003086-199008000-00038

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Implication

Review reveals essential morphogenic and mitogenic roles of fibroblast growth factors in early embryonic development, highlighting mechanisms underlying tissue formation and oncogenesis.

Fibroblast Growth Factor

Discussion

Member takes

Implication

Key Points

Cite This Study

Fibroblast Growth Factor

Discussion

Member takes

Implication

Key Points

Cite This Study

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