Observational study reveals microvessel counts predict metastatic spread in invasive breast carcinoma, indicating angiogenesis assessment can guide aggressive therapy selection.
The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both). Assessment of tumor angiogenesis may therefore prove valuable in selecting patients with early breast carcinoma for aggressive therapy.
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Weidner et al. (1991) studied this question.
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