Los puntos clave no están disponibles para este artículo en este momento.
Adverse drug reactions among elderly patients pose a significant clinical problem. The authors used a serum radioreceptor assay RRA to quantify drug-induced muscarinic blockade in 34 randomly selected nursing home residents. A random intervention group and the nonintervention control subjects were then retested 4 weeks later. The reduction of serum antimuscarinic activity (as determined by RRA) did relate to changes on several measures of cognitive function. A calculated "antimuscarinic index" lost significance with the RRA following intervention and may have overestimated the impact of a dosage reduction.
Tollefson et al. (Thu,) studied this question.