Patients with embolic stroke of undetermined source had significantly increased P-wave dispersion (34.14 vs 27.32 ms) and atrial electromechanical delay compared to healthy controls.
Cross-Sectional (n=56)
No
Are markers of atrial cardiopathy (P-wave dispersion, LA EMD, and LA volumes) increased in patients with embolic stroke of undetermined source compared to healthy controls?
Increased P-wave dispersion, atrial electromechanical delay, and left atrial volumes suggest that atrial cardiopathy is a distinct mechanism in patients with embolic stroke of undetermined source.
Tasa de eventos absoluta: 34.14% vs 27.32%
valor p: p=0.01
Recent research has shed light on the culpability of LA (left atrial) abnormality, in the form of atrial cardiopathy, as an independent risk factor for the development of atrial fibrillation, LA thrombus and subsequent stroke. The aim of this study was to measure LA electromechanical dissociation (EMD), LA volumes, P-wave dispersion (PWD) and P-wave terminal force in V1 (PTFV1) as markers of atrial cardiopathy in patients with ESUS (embolic stroke of undetermined source), to determine whether atrial cardiopathy is an integral part in the causal pathway of ESUS. 28 patients presenting with ischemic stroke and fulfilling the criteria for ESUS were enrolled into this cross-sectional, observational study along with a control group of 28 age- and gender-matched apparently healthy individuals. On ECG, PWD and PTFV1 were measured. On echocardiography, LA EMD and LA volumes were recorded. Increased PWD (34.14 ± 9.89 ms vs. 27.32 ± 8.95 ms; p = 0.01), atrial EMD (73.32 ± 16.31 ms vs. 63.63 ± 13.59 ms; p = 0.02) and LA volumes were observed in patients with ESUS as compared to controls. A significant correlation was also found between these parameters (p < 0.01). According to the results of our study, PWD, atrial EMD and LA volumes may be novel predictors for ESUS. Our results support the notion that atrial cardiopathy is a distinct mechanism of thrombosis in ESUS patients. Further research is required to clarify its function in the causation of stroke, ESUS in particular.
Masood et al. (Wed,) conducted a cross-sectional in Embolic stroke of undetermined source (ESUS) (n=56). ESUS (Exposure) vs. Healthy controls was evaluated on P-wave dispersion (ms) (p=0.01). Patients with embolic stroke of undetermined source had significantly increased P-wave dispersion (34.14 vs 27.32 ms) and atrial electromechanical delay compared to healthy controls.