Key result
ESUS is linked to ~7 ms greater P-wave dispersion and increased atrial electromechanical delay.
Why the study?
LA abnormality in the form of atrial cardiopathy is an independent risk factor for AF, LA thrombus, and stroke, but whether it is integral in the causal pathway of ESUS remained to be determined.
Are markers of atrial cardiopathy (P-wave dispersion, LA EMD, and LA volumes) increased in patients with embolic stroke of undetermined source compared to healthy controls?
Population
28 patients with ischemic stroke fulfilling ESUS criteria and 28 age- and gender-matched healthy controls
Comparison
ESUS patients vs age- and gender-matched healthy controls
Design
Cross-sectional, observational study
Authors
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May indicate atrial cardiopathy in ESUS; leaves open need for prospective validation and therapeutic trials.
Cross-Sectional (n=56)
No
Are markers of atrial cardiopathy (P-wave dispersion, LA EMD, and LA volumes) increased in patients with embolic stroke of undetermined source compared to healthy controls?
Absolute Event Rate: 34.14% vs 27.32%
p-value: p=0.01
Increased P-wave dispersion, atrial electromechanical delay, and left atrial volumes suggest that atrial cardiopathy is a distinct mechanism in patients with embolic stroke of undetermined source.
Masood et al. (2023) conducted a cross-sectional in Embolic stroke of undetermined source (ESUS) (n=56). ESUS (Exposure) vs. Healthy controls was evaluated on P-wave dispersion (ms) (p=0.01). Patients with embolic stroke of undetermined source had significantly increased P-wave dispersion (34.14 vs 27.32 ms) and atrial electromechanical delay compared to healthy controls.
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