What is the clinical evidence from this study?

Study design: Other. Population: Healthy (n=28). Intervention: Handgrip exercise training vs. Low intensity (25% of maximum voluntary contraction) handgrip exercise. Primary outcome: Increase in forearm blood flow after forearm occlusion (p=0.632).

December 31, 2001

Modification of Forearm Vascular Function Following Short-Term Handgrip Exercise Training

Resultado clave

Short-term handgrip exercise training at low or high intensity significantly increased forearm blood flow following occlusion, with no significant difference between intensity groups (p=0.632).

PICO estructurado

Does short-term handgrip exercise training improve localized vascular function in healthy men?

Población

28 healthy men (age: 23 +/- 4.3)

Intervención

4-week program of non-dominant handgrip exercise performed 5 days/week for 20 minutes at either low (25% of maximum voluntary contraction) or high (75% of maximum voluntary contraction) intensity

Comparador

Pre-training baseline and comparison between low and high intensity groups

Resultado

Forearm blood flow evaluated pre- and post-training at rest, following forearm occlusion, and following forearm occlusion combined with handgrip exercise using strain gauge plethysmographysurrogate

Short-term handgrip exercise training improves unilateral vasodilatory responsiveness in healthy men, with the degree of improvement appearing independent of the training intensity.

Resultado numérico

Tasa de eventos absoluta: 20.72% vs 16.51%

valor p: p=0.632

Resumen

This study examined the effect of low (25% of maximum voluntary contraction) and high (75% of maximum voluntary contraction) intensity short-term handgrip exercise training on localized vascular function. Forearm blood flow was evaluated in twenty-eight healthy men (age: 23 +/- 4.3) pre- and post-training in both forearms at rest, following forearm occlusion and following forearm occlusion combined with handgrip exercise using strain gauge plethysmography. The 4-week program consisted of non-dominant handgrip exercise performed 5 d/wk for 20 min at either low or high intensity. Following training a significant increase in forearm blood flow was noted for the nondominant arm in both groups after forearm occlusion (low intensity group: 16.51%; high intensity group: 20.72%; p = 0.001) and forearm occlusion combined with handgrip exercise (low intensity group: 17.71%; high intensity group: 29.27%; p = 0.001). No significant group by test interaction (p = 0.632) was found. These data show improved unilateral vasodilatory responsiveness after short-term handgrip training. In addition, the degree of change is most notable following the greatest vasodilatory stimulus. Lastly, a lack of group by treatment interaction suggests the change may be independent of training stimulus.

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