The SCN5A variant allele Y1102 is associated with cardiac arrhythmia in African Americans (P=0.000028) and may serve as a molecular marker for arrhythmia susceptibility.
Observational
valor p: p=0.000028
Every year, ∼450,000 individuals in the United States die suddenly of cardiac arrhythmia. We identified a variant of the cardiac sodium channel gene SCN5A that is associated with arrhythmia in African Americans ( P = 0.000028) and linked with arrhythmia risk in an African-American family ( P = 0.005). In transfected cells, the variant allele (Y1102) accelerated channel activation, increasing the likelihood of abnormal cardiac repolarization and arrhythmia. About 13.2% of African Americans carry the Y1102 allele. Because Y1102 has a subtle effect on risk, most carriers will never have an arrhythmia. However, Y1102 may be a useful molecular marker for the prediction of arrhythmia susceptibility in the context of additional acquired risk factors such as the use of certain medications.
Splawski et al. (Fri,) conducted a observational in Cardiac arrhythmia. SCN5A variant allele (Y1102) was evaluated on Arrhythmia (p=0.000028). The SCN5A variant allele Y1102 is associated with cardiac arrhythmia in African Americans (P=0.000028) and may serve as a molecular marker for arrhythmia susceptibility.
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