August 23, 2002Science
Variant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia
Key result
The SCN5A variant allele Y1102 is associated with cardiac arrhythmia in African Americans (P=0.000028) and may serve as a molecular marker for arrhythmia susceptibility.
Authors
Discussion
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Implication
Does not support clinical use of Y1102 testing; hypothesis-generating for arrhythmia susceptibility in African Americans.
Study Design
Type
Observational
PICO
P
Population
Cardiac arrhythmia
I
Intervention / Comparator
SCN5A variant allele (Y1102)
O
Primary Outcome
Arrhythmia, p=0.000028
Main Result
p-value: p=0.000028
Limitations
- Y1102 has a subtle effect on risk, most carriers will never have an arrhythmia
Cite This Study
Splawski et al. (2002) conducted an observational in Cardiac arrhythmia. SCN5A variant allele (Y1102) was evaluated on Arrhythmia (p=0.000028). The SCN5A variant allele Y1102 is associated with cardiac arrhythmia in African Americans (P=0.000028) and may serve as a molecular marker for arrhythmia susceptibility.