December 14, 2006Clinical Pharmacology & Therapeutics
A Common Polymorphism in SCN5A is Associated with Lone Atrial Fibrillation
Why the study?
Does the SCN5A H558R polymorphism increase the risk of early-onset lone atrial fibrillation in patients lacking traditional risk factors?
Population
157 patients with early-onset atrial fibrillation who lacked traditional risk factors, and 314 matched…
Comparison
Presence of the SCN5A H558R polymorphism. vs Absence of the SCN5A R558 allele / matched…
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
SCN5A R558 allele associated with early-onset lone AF; hypothesis-generating for genetic risk and sodium channel blocker proarrhythmia caution.
Key Points
- To determine whether common genetic variation in the cardiac sodium channel gene (SCN5A), specifically the H558R polymorphism, confers susceptibility to lone atrial fibrillation.
- Recruited 157 patients with early-onset lone atrial fibrillation lacking traditional cardiovascular risk factors and 314 matched controls.
- Conducted targeted genotyping of the SCN5A H558R loss-of-function polymorphism and comprehensive coding sequence mutation scanning.
- Genotype distributions differed significantly between atrial fibrillation cases and controls (HH: 50% vs 63%, HR: 40% vs 33%, RR: 10% vs 4%; P=0.008).
- The R558 allele was significantly more frequent in atrial fibrillation patients compared to controls (30% vs 21%, P=0.002), conferring an increased risk for atrial fibrillation (OR 1.6, 95% CI 1.2–2.2).
Structured PICO
Does the SCN5A H558R polymorphism increase the risk of early-onset lone atrial fibrillation in patients lacking traditional risk factors?
P
Population
157 patients with early-onset atrial fibrillation (AF) who lacked traditional risk factors, and 314 matched controls (total n=471).
I
Intervention
Presence of the SCN5A H558R polymorphism (R558 allele).
C
Comparator
Absence of the SCN5A R558 allele / matched controls.
O
Outcome
Presence of early-onset lone atrial fibrillation.
The SCN5A R558 allele is a common genetic risk factor for early-onset lone atrial fibrillation and may increase susceptibility to sodium channel blocker-induced proarrhythmia.
Cite This Study
Chen et al. (2006) studied this question.