Discovery of azaindole/indole-fused pyrimidine tetracyclic scaffolds as novel potent CDK7 inhibitors

Puntos clave

• The aim is to identify new chemical scaffolds that could effectively inhibit CDK7, a key protein involved in cell cycle regulation.
• Chemical synthesis of azaindole/indole-fused pyrimidine tetracyclic scaffolds.
• Evaluation of the potency against CDK7 in biological assays.
• Identified novel potent CDK7 inhibitors demonstrating strong biological activity.
• Showed potential for further pharmacokinetic optimization in drug development.