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May 28, 2026Journal of Enzyme Inhibition and Medicinal ChemistryOpen Access

Discovery of azaindole/indole-fused pyrimidine tetracyclic scaffolds as novel potent CDK7 inhibitors

Fan Pu Axiao Tao Pengxiang Qiu Weishan Deng Zijian Chen Zheng Cao Yunjiao He Peng George Wang Y Zhang Chengqing Ning Xuechen Li Jing Xu

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Key Points

The aim is to identify new chemical scaffolds that could effectively inhibit CDK7, a key protein involved in cell cycle regulation.
Chemical synthesis of azaindole/indole-fused pyrimidine tetracyclic scaffolds.
Evaluation of the potency against CDK7 in biological assays.
Identified novel potent CDK7 inhibitors demonstrating strong biological activity.
Showed potential for further pharmacokinetic optimization in drug development.

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Implication

Discovery of novel CDK7 inhibitors using azaindole/indole-fused pyrimidine scaffolds, suggesting new pharmacological applications.

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Cite This Study

Pu et al. (2026) studied this question.

synapsesocial.com/papers/6a1d212702fbce913063758d https://doi.org/10.1080/14756366.2026.2659998

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