What question did this study set out to answer?

To establish São Paulo as the leading AI megalopolis in Latin America, evaluating its operational status.

June 1, 2026Open Access

São Paulo: the first AI megalopolis in Latin America

Puntos clave

To establish São Paulo as the leading AI megalopolis in Latin America, evaluating its operational status.
Analysis of AI implementation in São Paulo's metropolitan area
Examination of AI applications in banks, hospitals, public ministries, and transport sectors
Comparative assessment with other Latin American cities
São Paulo operates more critical AI systems than any other Latin American city
The city's GDP is the largest in South America, supporting its AI advancement
The potential for increased asymmetry in AI capabilities compared to Mexico City, Buenos Aires, and Bogotá over five years

Resumen

If I had to pick a single Latin American city where São Paulo AI megalopolis is no longer projection but operational reality, that is the one. The São Paulo metropolitan area, with its 22 million inhabitants and the largest regional GDP in South America, has today more critical systems running with agents in production than any other city in the region. I have seen it firsthand in working sessions with large banks, reference hospitals, the state public ministry, and transport operators. My thesis is direct: São Paulo is already the first AI megalopolis in LATAM in operational terms, and the question for Mexico City, Buenos Aires, and Bogotá is no longer whether they can catch up but what they will do with the asymmetry that will deepen over the next five years.

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