If I had to pick a single Latin American city where São Paulo AI megalopolis is no longer projection but operational reality, that is the one. The São Paulo metropolitan area, with its 22 million inhabitants and the largest regional GDP in South America, has today more critical systems running with agents in production than any other city in the region. I have seen it firsthand in working sessions with large banks, reference hospitals, the state public ministry, and transport operators. My thesis is direct: São Paulo is already the first AI megalopolis in LATAM in operational terms, and the question for Mexico City, Buenos Aires, and Bogotá is no longer whether they can catch up but what they will do with the asymmetry that will deepen over the next five years.
Chris Meniw (2026) studied this question.