Signal-averaged electrocardiogram (SAECG) detects late potentials in 47-100% of patients with arrhythmogenic right ventricular dysplasia, with higher prevalence in severe disease and spontaneous VT.
Systematic Review
Does SAECG have utility in the diagnosis and prognosis of patients with ARVD?
SAECG is a useful diagnostic tool for detecting late potentials in ARVD, with higher prevalence in severe disease and spontaneous VT, and should be considered a standard part of evaluation.
BACKGROUND: Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by progressive replacement of RV myocardium with fibro-adipose tissue thought to be responsible for the presence of late potentials (LP) detected by SAECG. The general consensus on the role of SAECG in the diagnosis and prognosis of patients with ARVD is lacking. The purpose of this systematic review was to better define the role of SAECG in ARVD. METHODS: An extensive review of literature was done to specifically describe the prevalence of LP in ARVD and its determinants, explore the various options available to improve the diagnostic ability of SAECG, and provide recommendations for proper utilization of this technique. RESULTS: LPs are frequent in ARVD (47-100%), and more prevalent in severe disease and in patients with documented spontaneous VT. SAECG is a useful test in following the characteristic evolutivity of the disease. 4-16% of normal family members of patients with ARVD also have abnormal SAECG results. Detection of LP in ARVD can be improved by employing a high-pass filter of 25 Hz and specifically looking for changes in the Z leads. CONCLUSIONS: SAECG testing should be considered a standard part of the evaluation of patients with known or suspected ARVD. Further research is needed to confirm the value of SAECG testing in predicting arrhythmia risk and assessing the rate of disease progression, as well as to determine if greater prevalence of SAECG abnormalities in family members of patients with ARVD represents early detection of ARVD. The ongoing multidisciplinary study of right ventricular dysplasia will hopefully answer some of these questions.
Nasir et al. (Tue,) conducted a systematic review in Arrhythmogenic Right Ventricular Dysplasia (ARVD). Signal-averaged electrocardiogram (SAECG) was evaluated on Prevalence of late potentials (LP). Signal-averaged electrocardiogram (SAECG) detects late potentials in 47-100% of patients with arrhythmogenic right ventricular dysplasia, with higher prevalence in severe disease and spontaneous VT.
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