Phylogenetic analysis of HEV71 strains revealed that multiple genogroups, including B3, B4, C1, C2, and a newly identified C3, have co-circulated and caused major outbreaks in the Asia-Pacific region since 1997.
Observational (n=128)
This molecular epidemiology study demonstrates that multiple genogroups of HEV71 have co-circulated in the Asia-Pacific region, highlighting the need for continued virological surveillance.
This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002. Phylogenetic analysis of the VP4 and VP1 genes of recent HEV71 strains indicates that several genogroups of the virus have been circulating in the Asia-Pacific region since 1997. The first of these recent outbreaks, described in Sarawak (Malaysian Borneo) in 1997, was caused by genogroup B3. This outbreak was followed by large outbreaks in Taiwan in 1998, caused by genogroup C2, and in Perth (Western Australia) in 1999, where viruses belonging to genogroups B3 and C2 cocirculated. Singapore, Taiwan, and Sarawak had HEV71 epidemics in 2000, caused predominantly by viruses belonging to genogroup B4; however, large numbers of fatalities were observed only in Taiwan. HEV71 was identified during an epidemic of hand, foot and mouth disease in Korea; that epidemic was found to be due to viruses constituting a new genogroup, C3.
Cardosa et al. (Tue,) conducted a observational in Human enterovirus 71 (HEV71) infection (n=128). HEV71 strain isolation and sequencing was evaluated on Genogroup classification based on VP1 and VP4 gene sequences. Phylogenetic analysis of HEV71 strains revealed that multiple genogroups, including B3, B4, C1, C2, and a newly identified C3, have co-circulated and caused major outbreaks in the Asia-Pacific region since 1997.
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