Review highlights berberine's effectiveness in improving diabetes outcomes through anti-inflammatory and metabolic actions, indicating its clinical potential.
Key Points
This review aims to summarize the therapeutic potential and mechanisms of berberine in managing type 2 diabetes.
Systematic review of literature from PubMed and Web of Science up to 2025
Analysis of berberine's pharmacological activities and molecular mechanisms
Assessment of berberine's effects on T2DM complications and synergistic therapies.
Berberine significantly enhances insulin sensitivity and regulates glucose metabolism through multiple pathways.
It demonstrates anti-inflammatory and antioxidant activities, targeting key signaling pathways like AKT and AMPK.
The article reviews clinical and preclinical applications of berberine, highlighting its potential in combination therapy.