Higher pre-gravid blood pressure was associated with a greater blood pressure drop in early pregnancy, whereas women with the lowest pre-gravid blood pressure showed no obvious drop throughout pregnancy.
Cohort (n=1,282)
No
This study challenges the widely accepted concept of a mid-trimester blood pressure drop during pregnancy, demonstrating that blood pressure trajectories depend heavily on pre-gravid blood pressure levels.
The study aims to examine the blood pressure (BP) trajectory during pregnancy and its association with pre-gravid BP level. In a pre-conception cohort study, newly-married women in Liuyang, China underwent pre-gravid measurements and were followed throughout the pregnancy. BP was measured at pre-conception and again throughout pregnancy. The functional principal component analysis was used to examine the trajectory of BP changes during pregnancy. A total of 1282 women with a singleton pregnancy who had both pre-conception and gestational BP measurements performed were included in the final analysis. The results showed that BP decreased significantly in early pregnancy and increased thereafter, without BP drop around 20 weeks of gestation. Pre-gravid BP level was inversely associated with the BP drop in early pregnancy, such that women with higher pre-gravid BP had greater BP drop at the beginning, while women with the lowest pre-gravid BP level demonstrated no obvious BP drop throughout the entire pregnancy.
Shen et al. (Tue,) conducted a cohort in Pregnancy (n=1,282). Pre-gravid blood pressure vs. Lowest pre-gravid blood pressure tertile was evaluated on Trajectory of blood pressure change during pregnancy. Higher pre-gravid blood pressure was associated with a greater blood pressure drop in early pregnancy, whereas women with the lowest pre-gravid blood pressure showed no obvious drop throughout pregnancy.
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