What is the clinical evidence from this study?

Study design: Observational. Population: Cancer survivors. Intervention: Cancer survivorship and associated risk factors. Primary outcome: Frequency of cardiac death and heart disease-specific survival rates (p=<0.0001).

June 16, 2017

Risk of cardiac death among cancer survivors in the United States: a SEER database analysis

Q: What are the key findings of this study?

Male gender, older age at diagnosis, black race, and radiotherapy were associated with a higher likelihood of cardiac death among cancer survivors >5 years (P<0.0001).

Resultado clave

Male gender, older age at diagnosis, black race, and radiotherapy were associated with a higher likelihood of cardiac death among cancer survivors >5 years (P<0.0001).

Diseño del estudio

Tipo

Observational

Multicéntrico

Sí

PICO estructurado

What is the risk and frequency of cardiac death among long-term (>5 years) cancer survivors?

Población

Cancer survivors (>5 years) from the US SEER database evaluated for the frequency and risk factors of cardiac death.

Resultado

Frequency of cardiac death compared to other causes of death, and heart disease-specific and cancer-specific survival rates.hard clinical

Cardiac death is a significant cause of mortality among long-term cancer survivors, highlighting the need for cardiovascular risk management in this population.

Resultado numérico

valor p: p=<0.0001

Resumen

BACKGROUND: Population-based data on the risk of cardiac death among cancer survivors are needed. This scenario was evaluated in cancer survivors (>5 years) registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database was queried using SEER*Stat to determine the frequency of cardiac death compared to other causes of death; and to determine heart disease-specific and cancer-specific survival rates in survivors of each of the 10 most common cancers in men and women in the SEER database. RESULTS: For cancer-specific survival rate, the highest rates were related to thyroid cancer survivors; while the lowest rates were related to lung cancer survivors. For heart disease-specific survival rate, the highest rates were related to thyroid cancer survivors; while the lowest rates were related to both lung cancer survivors and urinary bladder cancer survivors. The following factors were associated with a higher likelihood of cardiac death: male gender, old age at diagnosis, black race and local treatment with radiotherapy rather than surgery (P 5 years), cardiac death is a significant cause of death and there is a wide variability among different cancers in the relative importance of cardiac death vs. cancer-related death.

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